Monday, June 29, 2015
Anyway, I was honored to be the final Show and Tell talk, featured in the closing plenary, where I was proud to offer a small tribute to my QS mentor Seth Roberts.
Saturday, June 27, 2015
It was especially interesting to talk to a former guard, a retired guy who likes to spend his Saturdays volunteering as a docent. He says that although the guards were outnumbered about 80 to one, they typically walk through the prison and interact one-on-one with prisoners and after working there a while, the inmates and guards become pretty friendly with one another. The New York prison escape is in the news, so we asked and he says it can only have been possible if there was widespread corruption among the staff. All the other prisoners must have known the details of the escape while it was being planned. It’s just a thing among prisoners that they all get to know one another, there are no secrets, and there are no snitches.
Yes, homosexual activity is extremely common. Especially if you’re a young, white man, he says, you will certainly be a target, and you may as well just get used to it. In the showers, in the laundry room — the guards just can’t watch everyone all the time. The prisoners repeat over and over that they’re not gay, it's just something they all need to do.
You should have see the clever weapons and other confiscated contraband. Plenty of sharpened screwdrivers, spoons, scissors, etc, but other things too: one guy even made a working set of walkie-talkies. Some of the prisoners had TV sets in their cells, which apparently is completely okay as long as it was purchased in the prison store.
From the upper level of the museum cell block, you could look out over the entire facility and see current inmates walking to and fro. I think Michigan must be fairly progressive in its policies (they banned capital punishment in 1846) because the prisoners are all kept busy, on everything from making license plates to growing trees. They have one big rule, though: no prisoner can earn money or be assigned a non-cleanup job, unless they pass their GED.
It feels good to be tough on crime, to think it’s okay for prisons to be cruel places where they get what they deserve, but you need to remember that many of these inmates are fundamentally good people who just made a mistake. I imagine what it must be like to have your own son or brother in jail, and how you’d want the place to be fair to him. Sixty percent of those who are released end up coming back to prison, partly because there are so few things they can legally do on the outside. Many of them study for business degrees, intending to start their own businesses, like landscaping or home repair. Many of them end up in food service, as cooks, waiters, dish washers, etc.
Friday, June 26, 2015
Here’s the cover of a magazine I saw yesterday in the grocery store checkout lane:
I thought about submitting it to Jonathan Eisen's list of Overselling the Microbiome, but sadly, I don’t think it would make the cut. These types of articles are becoming too common to deserve an award.
There is surprisingly little that is known about the microbiome, and for every study that shows some connection between this or that microbe and this or that condition, there are counter-examples galore. Some of it is a measurement issue: even if you do sample a person’s microbiome, are you sure it’s a representative sample? Studies of gut microbes are nearly always made on the organisms that exit the body, so by definition any measurement is of something that is no longer bioactive.
I’m interested in the microbiome because I think the whole subject is incredibly fascinating, and I believe that eventually science will find some deep insights that will radically alter the way we think about what it means to be human. I hold out hope that we may find a few tricks to manipulate the microbiome in some specific cases, and certainly in general it is good to learn more about how our bodies work.
But c’mon people, tone it down a little.
Thursday, June 25, 2015
At the Microbiome breakout during last week’s Quantified Self Conference, several people were interested in the list of organisms I track.
Here’s the list, along with my own results for the past seven samples:
Why this particular list? I’ll be honest: no particularly strong reasons. Most of these are derived from various conversations with the super-knowledgable Grace Liu, now based at The Gut Institute. I strongly encourage you to follow her there, and on twitter @gut_goddess for better information.
Note: after speaking more with experts at uBiome and elsewhere, I’ve concluded that it’s okay to trust the species information for many of the organisms, including the ones above. Although 16S rRNA is not very reliable at detecting anything below the genus level in general, there are some organisms where the genus is the relevant species. Sure, I suppose it’s theoretically possible that another species may exist as part of that genus, but in reality none has been found in humans.
Also note: even the word “species” doesn’t mean the same thing for bacteria that it means when speaking of lifeforms like humans that reproduce sexually. After all, bacteria reproduce by simply dividing in half. There is no concept of of a “species divide” like that one that prevents a dog, for example, from reproducing with a cat. There is plenty of gene transfer and gene mixing that occurs among bacteria, but that often (perhaps usually) crosses the lines of what we might think of as unique species.
The bottom line: don’t get too hung up on a particular species. If something is biologically active, it may not matter whether you’re tracking at the genus level or the species level. Well, maybe it matters, but for most purposes you won’t get any closer by knowing the species name. In some ways, knowing that something is a member of a particular species can give you a false sense of confidence, when in reality science knows far less about the activities of these organisms than we would all hope.
Do you have any specific organisms that you like to track?
Wednesday, June 24, 2015
By tradition and by default, books aren’t verified to anything near the standard of a magazine piece.
- Medical and health information is notoriously inaccurate, even from sources you’d hope you can trust. For decades, the Center for Science in the Public Interest, as well as the National Academy of Sciences, encouraged the American public to eat trans-fats.
- A quote regularly repeated by New York Times op-ed author David Brooks, about a rising sense of self-importance among American adolescents appears to be entirely wrong.
- Many, many books have been retracted, or published with disclaimers
Tuesday, June 23, 2015
Ecosystems go all the way up and all the way down. Just as humans affect -- and are affected -- by the bigger world of animals, forests, oceans, and sky, we are also part of a deeper micro-sized world of bacteria and viruses, many (most?) of them far older than we are, and constantly adapting to all the harshness of life, including the new realities of human-made antibiotics and hygiene. Control over nature is an old goal of science, but nature is never fooled forever. The great bridges and dams that make one side of our lives better can have unforeseen consequences to other parts of our world.
Monday, June 22, 2015
I’m back from two jam-packed days at the QS15 (the Quantified Self Conference) held at Fort Mason, in San Francisco, and I have a few impressions.
There were three “cool” new ideas that I thought played an outsize role at this conference:
1. All things Microbiome
(obviously I would think so). uBiome was there, including an appearance at the first day’s plenary by Jessica Richman. My tweet (and heavily retweeted) summary of the session was a quote from the first speaker: “We are the last generation without personalized medical data”. That’s true for the microbiome especially, and it was wonderful talking with so many people about their new bacterial experiments. I’ll write more in future posts.
2. Heart Rate Variability
With better technology for measuring heart rates, many people have noticed that pulse/minute is a less useful measure than variability. Sometimes it’s more meaningful to look at how much each heart wave length varies from the others: high variability tends to be associated with creativity or improved mental processing, whereas low variability tends to be accompanied by stress or low learning situations.
Paul LaFontaine used HRV measurements to demonstrate that he is more nervous in situations involving presentations to groups of people than he is in situations reporting to a superior. Mark Leavitt showed it as a way to measure willpower.
3. Direct Cranial Stimulation
I thought this was fringe stuff when I first heard of it a few years ago, but enough people have tried it that I’m starting to rethink my skepticism. JD Leadam even has a company, https://thebrainstimulator.net/ selling devices for a little over $100.
I was especially impressed by a breakout session led by Evian Gordon (http://mybrainsolutions.com) who seemed to know a ton about every imaginable aspect of assessing mental performance. Anyone interested in Seth’s Brain Tracker would want to understand what those guys are doing as well. Daniel Gartenberg is another psychology expert in attendance who I knows a lot about this subject. I had good results beta-testing an app he wrote that claims to help with deep sleep, so it was nice to talk with him in person again.
What I didn’t see: Apple Watch. Oh sure, there were some discussions of HealthKit and ResearchKit, but unlike QS15, which seemed to be attended by a significant percentage of the world’s Google Glass wearing population, I saw very few Apple Watches. Whether this is because the availability is still so limited or whether the QS early adopters just haven’t taken to the Watch yet — I don’t know.
I’m expecting that http://quantifiedself.com will dish out many more details in upcoming days and weeks. Worth watching further.
Thursday, June 11, 2015
That’s what’s supposed to happen, but unfortunately the inanity of the American healthcare system gets in the way, and today was the second time I’ve been unhappily surprised at the results.
The front end works fine. I entered my information and quickly found a list of doctors in my area that meet my requirements, including availability times. I hit submit and that was it: a nice, professional confirmation for a visit with a doctor with good reviews. They even added the appointment automatically to my iPhone calendar, and offered to text me a reminder before the visit. ZocDoc already knows my insurance and basic health information, so I didn’t even need to fill out additional forms for the visit. Perfect!
Unfortunately, that’s as far as the resemblance to OpenTable restaurant reservations ends. I had scheduled my appointment for 1pm, right after lunch in the area close to where I knew I was going, but early on the day of the appointment I received an odd email from a different doctor confirming my appointment for 11am. The ZocDoc site knew nothing about this, so I called the new doctor to see what was happening.
The new doctor’s receptionist was confused too. From her point of view, I had made an appointment at 11am. If I didn’t show up on time, or if I canceled the appointment less than 24 hours beforehand, she would charge me a fee. The fact that I had booked it through ZocDoc — and that I had a different time confirmed — was not relevant to her.
Well, I shifted things around so that I was able to make the 11am appointment, but frustratingly, when I arrived I had to fill in all the forms (again). A cheerful physician’s assistant brought me into the exam room, took my vital signs and then, almost as a side comment, warned that my insurance company probably wouldn’t reimburse me for today’s visit. What!?
By then, it was really too late for me to get up and walk out the door. The doctor arrived, I had my brief appointment (I wanted somebody to look at a suspicious mole) and that was it. No problems, I’m fine.
Later, at the original ZocDoc appointment time, I received that promised text message reminding me of my visit and helpfully offering to give me additional support if I reply with the message ’s’. I did, and talked with a very kind, helpful ZocDoc representative who assured me that they do everything possible to ensure that I have a good experience, blah blah blah.
This is turning into a long rant and I appreciate, dear reader, your indulgence as I get this off my chest. But it occurs to me that ZocDoc is in a business that is fundamentally so different from OpenTable, that it may be impossible to give me a good experience. Unlike OpenTable, ZocDoc’s “customers” (physicians pay them a flat monthly fee to be listed on the site) already have too many IT systems. From insurance and Medicaid reimbursement to government-mandated certification, HIPAA, and reporting requirements, their staff is probably just too busy to deal with yet another web site. Solving that “last-mile” problem with the receptionists would require much more training and hand-holding than ZocDoc can afford.
Eventually all of this will be sorted out and sometime in the future doctors will join the 20th century IT revolution just like every other industry, but it will be a long time. If you want high-tech, don’t go to the doctor: go to a restaurant.